Hypersensitivity reactions (eg, anaphylaxis, rash) may occur following administration. Not to be used to treat acute asthma exacerbations. Advise patients to seek medical advice if their asthma remains uncontrolled or worsens after treatment initiation. Abrupt corticosteroid discontinuation after initiation of Tezspire therapy is not recommended; reduce dose gradually, if appropriate. Known helminth infection; discontinue use if the patient becomes infected while receiving Tezspire treatment & does not respond to anti-helminth treatment. Serious cardiac adverse events may occur; discontinue use until acute event stabilises, if the patient develops a serious cardiac event during treatment. Treat preexisting serious infections prior to Tezpire treatment initiation. Not recommended to be used during pregnancy. Lactation; consider the benefit & risk of breast-feeding for the child & the benefit of therapy for the woman.