Drug- & disease-induced constipations. Consider dose reduction, drug w/drawal, or discontinuation if abdominal pain or diarrhoea occurs. Periodically assess the need for suspended or continued therapy. Serious liver disorder (eg, biliary obstruction or reduced bile acid secretion). Pregnant women & women who may possibly be pregnant. Discontinue breastfeeding during treatment. Low birth wt infants, neonate, nursing infants, infants or ped patients. Reduce dose in the elderly.
May interfere w/ reabsorption of bile acid prep (eg, ursodeoxycholic acid, chenodeoxycholic acid). May attenuate the effects w/ Al-containing antacids (eg, sucralfate hydrate, aldioxa), cholestyramine & colestimide. May elevate & enhance effects of digoxin, dabigatran etexilate, methanesulfonate. May decrease blood levels & effects of midazolam.
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